This section will be updated as results become available
We expect further assessment of the nature and intensity of the reproductive responses to selected compounds and complex mixtures. The direct impacts of the project will be:
1. Deciphering the signaling cascades and transcriptional factors in the EDC-exposed ovarian cells to better understand the molecular mechanisms of EDC action in the ovary, in particular those closely linked to disease conditions.
2. Through the in vitro approach, the EcoSignal project will identify specific targets of EDC action in the ovarian cells. Only on the basis of such research it will be possible to develop the appropriate biomarkers and bio-tests of effects for human disorders.
3. Provides novel hypothesis-driven predictions that connect EDC exposure and women’s reproductive diseases.
This work should facilitate:
1. Risk assessment process;
2. Connection between the chemical exposures and human diseases.